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Year Number of Results
2005 1
2006 2
2008 2
2010 1
2012 1
2013 5
2014 2
2015 4
2016 3
2017 1
2018 4
2019 6
2020 5
2021 5
2022 4
2023 6
2024 2

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50 results

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Page 1
Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells.
Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, Zhou B, Chen J, Gao S, Zhang X, Jia M, Niu C, Yang W, Zhi X, Wang X, Yu D, Bai L, Wang L, Na J, Zou Y, Zhang J, Zhang S, Meng D. Wei X, et al. Sci Adv. 2019 Mar 13;5(3):eaau7887. doi: 10.1126/sciadv.aau7887. eCollection 2019 Mar. Sci Adv. 2019. PMID: 30891497 Free PMC article.
The transcription factor BTB and CNC homology 1 (Bach1) is expressed in the embryos of mice, but whether Bach1 regulates the self-renewal and early differentiation of human embryonic stem cells (hESCs) is unknown. We report that the deubiquitinase ubiquitin-specific …
The transcription factor BTB and CNC homology 1 (Bach1) is expressed in the embryos of mice, but whether Bach1 regulates the s …
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation.
Jia M, Li Q, Guo J, Shi W, Zhu L, Huang Y, Li Y, Wang L, Ma S, Zhuang T, Wang X, Pan Q, Wei X, Qin Y, Li X, Jin J, Zhi X, Tang J, Jing Q, Li S, Jiang L, Qu L, Osto E, Zhang J, Wang X, Yu B, Meng D. Jia M, et al. Circ Res. 2022 Apr;130(7):1038-1055. doi: 10.1161/CIRCRESAHA.121.319540. Epub 2022 Feb 24. Circ Res. 2022. PMID: 35196865
However, the role and underlying mechanisms of BACH1 in atherosclerosis remain unclear. METHODS: Mouse models of atherosclerosis in endothelial cell (EC)-specific-Bach1 knockout mice were used to study the role of BACH1 in the regulation of atherogenesis and …
However, the role and underlying mechanisms of BACH1 in atherosclerosis remain unclear. METHODS: Mouse models of atherosclerosis in e …
Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders.
Ryter SW. Ryter SW. Antioxidants (Basel). 2022 Mar 15;11(3):555. doi: 10.3390/antiox11030555. Antioxidants (Basel). 2022. PMID: 35326205 Free PMC article. Review.
This review will present evidence for beneficial effects of HO-1 and its reaction products in human diseases, including cardiovascular disease (CVD), metabolic conditions, including diabetes and obesity, as well as acute and chronic diseases of the liver, kid …
This review will present evidence for beneficial effects of HO-1 and its reaction products in human diseases, including cardiovasc …
Cardiac-specific BACH1 ablation attenuates pathological cardiac hypertrophy by inhibiting the Ang II type 1 receptor expression and the Ca2+/CaMKII pathway.
Wei X, Jin J, Wu J, He Y, Guo J, Yang Z, Chen L, Hu K, Li L, Jia M, Li Q, Lv X, Ge F, Ma S, Wu H, Zhi X, Wang X, Jiang L, Osto E, Zhang J, Meng D. Wei X, et al. Cardiovasc Res. 2023 Aug 7;119(9):1842-1855. doi: 10.1093/cvr/cvad086. Cardiovasc Res. 2023. PMID: 37279500
This research investigates the function and mechanisms of BACH1 in the regulation of cardiac hypertrophy. METHODS AND RESULTS: Male cardiac-specific BACH1 knockout mice or cardiac-specific BACH1 transgenic (BACH1-Tg) mice and their respective wild-type …
This research investigates the function and mechanisms of BACH1 in the regulation of cardiac hypertrophy. METHODS AND RESULTS: Male c …
Regulation of the MIR155 host gene in physiological and pathological processes.
Elton TS, Selemon H, Elton SM, Parinandi NL. Elton TS, et al. Gene. 2013 Dec 10;532(1):1-12. doi: 10.1016/j.gene.2012.12.009. Epub 2012 Dec 14. Gene. 2013. PMID: 23246696 Review.
MiR-155-5p is one of the best characterized miRNAs and recent data indicate that miR-155-5p plays a critical role in various physiological and pathological processes such as hematopoietic lineage differentiation, immunity, inflammation, viral infections, cancer, cardiovascular …
MiR-155-5p is one of the best characterized miRNAs and recent data indicate that miR-155-5p plays a critical role in various physiological a …
Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1.
Nishizawa H, Matsumoto M, Shindo T, Saigusa D, Kato H, Suzuki K, Sato M, Ishii Y, Shimokawa H, Igarashi K. Nishizawa H, et al. J Biol Chem. 2020 Jan 3;295(1):69-82. doi: 10.1074/jbc.RA119.009548. Epub 2019 Nov 18. J Biol Chem. 2020. PMID: 31740582 Free PMC article.
Our findings suggest that BACH1 represses genes that combat labile iron-induced oxidative stress, and ferroptosis is stimulated at the transcriptional level by BACH1 upon disruption of the balance between the transcriptional induction of protective genes and accumul …
Our findings suggest that BACH1 represses genes that combat labile iron-induced oxidative stress, and ferroptosis is stimulated at th …
Acute ischemia induces spatially and transcriptionally distinct microglial subclusters.
Li H, Liu P, Zhang B, Yuan Z, Guo M, Zou X, Qian Y, Deng S, Zhu L, Cao X, Tao T, Xia S, Bao X, Xu Y. Li H, et al. Genome Med. 2023 Dec 11;15(1):109. doi: 10.1186/s13073-023-01257-5. Genome Med. 2023. PMID: 38082331 Free PMC article.
ICAM, induced by damage-associated molecular patterns, are probably fueled by glycolysis, and exhibit increased pro-inflammatory cytokines and chemokines production. BACH1 is a key transcription factor driving ICAM generation. In contrast, glucocorticoids, which are enrich …
ICAM, induced by damage-associated molecular patterns, are probably fueled by glycolysis, and exhibit increased pro-inflammatory cytokines a …
Inhibiting BTB domain and CNC homolog 1 (Bach1) as an alternative to increase Nrf2 activation in chronic diseases.
Mafra D, Alvarenga L, Cardozo LFMF, Stockler-Pinto MB, Nakao LS, Stenvinkel P, Shiels PG. Mafra D, et al. Biochim Biophys Acta Gen Subj. 2022 Jun;1866(6):130129. doi: 10.1016/j.bbagen.2022.130129. Epub 2022 Mar 12. Biochim Biophys Acta Gen Subj. 2022. PMID: 35292311 Review.
Studies have shown that Nrf2 expression is downregulated and Bach1 expression upregulated in many chronic diseases; hence Nrf2 activators and Bach1 inhibitors need to be investigated for their potential to mitigate inflammation and improve antioxidant respons …
Studies have shown that Nrf2 expression is downregulated and Bach1 expression upregulated in many chronic diseases; hence Nrf2 …
BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
Zhang T, Yang M, Ma C, Wei X, Zhang Z. Zhang T, et al. Eur J Neurosci. 2023 Jul;58(1):2194-2214. doi: 10.1111/ejn.16035. Epub 2023 May 31. Eur J Neurosci. 2023. PMID: 37161649
It has been confirmed that BTB domain and CNC homologue 1 (BACH1) are involved in ferroptosis-related diseases. However, the function of BACH1 in cerebral ischemia-reperfusion injury (CIRI)-induced ferroptosis remains to be largely unrevealed. ...Mechanistica …
It has been confirmed that BTB domain and CNC homologue 1 (BACH1) are involved in ferroptosis-related diseases. However, the f …
Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling.
Chen Y, Guo X, Zeng Y, Mo X, Hong S, He H, Li J, Steinmetz R, Liu Q. Chen Y, et al. Free Radic Biol Med. 2023 Oct;207:227-238. doi: 10.1016/j.freeradbiomed.2023.07.025. Epub 2023 Jul 25. Free Radic Biol Med. 2023. PMID: 37499888 Free article.
Isoproterenol also promoted heme oxygenase 1 (HO-1) expression by downregulating the transcription suppressor BTB and CNC homology 1 (Bach1), leading to increased labile iron accumulation through heme degradation. ...Taken together, our results reveal that catecholamine st …
Isoproterenol also promoted heme oxygenase 1 (HO-1) expression by downregulating the transcription suppressor BTB and CNC homology 1 (Bac …
50 results